Fluoxymesterone Oral
Haloplex 10 mg contains fluoxymesterone, a potent 17α-alkylated anabolic-androgenic steroid derived from testosterone. It is a halogenated derivative with a 9α-fluoro group and an 11β-hydroxy group, which increases its anabolic potency relative to testosterone. The oral bioavailability is high due to the 17α-methyl group, which resists first-pass hepatic metabolism, but this same modification confers significant hepatotoxicity.
Fluoxymesterone was FDA-approved under the brand name Halotestin for replacement therapy in male hypogonadism and delayed puberty, and for palliation of androgen-responsive recurrent mammary cancer in postmenopausal women. **All Halotestin products are now discontinued**. The FDA label explicitly states that the drug has not been shown to be safe and effective for athletic performance enhancement and should not be used for that purpose.
In bodybuilding contexts, fluoxymesterone is referenced for its ability to increase aggression, strength, and muscle hardness without significant water retention or aromatization. However, it is a **Schedule III controlled substance** and is **prohibited at all times by WADA** under S1.1 Anabolic Androgenic Steroids. Documented adverse effects include cholestatic jaundice, hepatic adenomas, peliosis hepatis, and virilization in women. Such use falls outside approved indications.
Research Properties of Haloplex 10 mg
- Potent 17α-alkylated oral anabolic steroid
- FDA-approved (historical) for male hypogonadism and breast cancer palliation
- All FDA-approved products now discontinued
- WADA S1.1 prohibited substance, banned at all times
- 10 mg per tablet for research applications
17α-Alkylated Anabolic Steroid
Fluoxymesterone is a synthetic androgen structurally related to testosterone, modified with a 9α-fluoro group, an 11β-hydroxy group, and a 17α-methyl group. These modifications increase anabolic potency and oral bioavailability while reducing androgenic activity relative to testosterone. The elimination half-life after oral administration is approximately 9.2 hours.
A 1977 study in nine normal male volunteers demonstrated that fluoxymesterone at 10–30 mg daily for twelve weeks produced a profound suppression of plasma testosterone levels within 24 hours of beginning treatment, with further reductions throughout the treatment period. Notably, plasma LH and FSH levels were not significantly altered, suggesting a local effect on Leydig cell function rather than suppression via gonadotropin inhibition.
Genotoxicity studies have shown that fluoxymesterone induces chromosome aberrations and sister chromatid exchanges in cultured human lymphocytes and increases micronuclei frequencies in mouse bone marrow cells, indicating clastogenic potential.
Defining Characteristic
Potent Oral Anabolic with Hepatotoxicity
Fluoxymesterone's defining pharmacological characteristic is its high oral potency combined with significant hepatotoxicity due to the 17α-alkylated structure, which is associated with cholestatic jaundice, hepatic adenomas, and peliosis hepatis.
Haloplex 10 mg vs Other Axiolabs Preparations
Axiolabs offers several anabolic compounds referenced in bodybuilding research. Stanoplex 50 (stanozolol) is another 17α-alkylated oral steroid with less androgenic activity. Methanoplex 50 (methandienone) is a more aromatizable oral with greater water retention. Oxandroplex (oxandrolone) is a milder oral anabolic steroid with a more favorable safety profile. Fluoxymesterone is distinguished by its high potency and profound androgenic effects.
Typical Dosage Ranges
The FDA-approved dose for male hypogonadism was 5–20 mg daily, and for breast cancer palliation 10–40 mg daily. In non-medical bodybuilding contexts, fluoxymesterone is commonly referenced at 10–40 mg daily, with cycles typically not exceeding 4–6 weeks due to hepatotoxicity concerns. Reference ranges vary, and higher doses or longer cycles increase the risk of cholestatic liver injury.
| Use Case |
Common Reference Range |
Frequency |
| Medical (male hypogonadism, historical) |
5–20 mg |
Daily |
| Medical (breast cancer palliation, historical) |
10–40 mg |
Daily |
| Bodybuilding (non-medical) |
10–40 mg |
Daily, short cycles |
Post-Cycle Therapy (PCT)
Fluoxymesterone suppresses endogenous testosterone production. In non-medical contexts, PCT is commonly recommended after cycles to restore natural testosterone production. Typical protocols reference tamoxifen or clomiphene for 4 weeks, starting after the last dose. Recovery of testosterone production varies based on cycle length and individual factors.
Managing Side Effects
Liver enzyme elevations are expected with fluoxymesterone use and should be monitored. Cholestatic jaundice presents with dark urine, pale stool, pruritus, and right-upper-quadrant discomfort; these symptoms warrant immediate discontinuation and medical evaluation. Women should be monitored for virilization signs including voice deepening, which may be irreversible.
Important
Individual Response Varies
The information above is for educational reference and does not constitute medical advice. Fluoxymesterone is not approved for athletic performance enhancement.
Important Safety Information
Fluoxymesterone is contraindicated in pregnancy (Category X), in males with carcinoma of the breast or known/suspected prostate cancer, and in patients with serious cardiac, hepatic, or renal disease. Prolonged use of high doses of 17α-alkylated androgens has been associated with hepatic adenomas, hepatocellular carcinoma, and peliosis hepatis—all potentially life-threatening complications. The FDA label states the drug has not been shown to be safe and effective for athletic performance enhancement.
Important
Non-Medical Use
Non-medical use of fluoxymesterone falls outside approved indications. It is prohibited in sport by WADA at all times and is a Schedule III controlled substance.
Potential Adverse Effects
Common adverse effects include acne, edema, breast soreness, priapism, and menstrual irregularities. Serious effects include cholestatic jaundice, hepatic neoplasms, peliosis hepatis, and virilization in women (deepening of voice, clitoral enlargement) that may be irreversible. Androgens may decrease levels of thyroxine-binding globulin and alter thyroid function tests. Oligospermia may occur at high dosages.
Conditions Requiring Medical Evaluation
Fluoxymesterone should not be used in patients with serious cardiac, hepatic, or renal disease. Caution is advised in patients with benign prostatic hypertrophy, as acute urethral obstruction may develop. Geriatric patients may be at increased risk of prostatic hypertrophy and carcinoma.
Monitoring Considerations
Because of hepatotoxicity associated with 17α-alkylated androgens, liver function tests should be obtained periodically during therapy. Hemoglobin and hematocrit should be checked periodically to detect polycythemia. Serum cholesterol may increase during androgen therapy.
Product Care
Storage & Handling
Store tablets in a closed container at controlled room temperature, away from excessive heat, moisture, and direct light. Keep out of reach of children. Do not use if the packaging is damaged or if tablets appear discolored.
Further Safety Information
USA Domestic 3–5 business days
International 10–15 business days
Order Processing 24–48 business hours
Tracking Provided after dispatch
Direct Supply
Discreet Delivery & Original Packaging
The outer shipping package remains discreet, with no external product details. Products are supplied through the official Axiolabs distribution chain.
What to Expect
- Orders are processed after payment confirmation
- USA Domestic shipping is typically faster when local stock is available
- International orders include tracking, though update frequency may vary by destination
- Multiple warehouses may result in separate shipments when applicable
Authenticity Verification
To verify your Haloplex 10 mg product, use the security code on the packaging and cross-check it on the official Axiolabs site. A credible certificate of analysis should show HPLC purity above 95 percent and mass spectrometry confirmation of the correct molecular weight (336.4 g/mol for fluoxymesterone). Original packaging and batch documentation help reinforce product legitimacy.
For complete delivery details, tracking policy, and reshipment terms, please see our Shipping Info page.
Recommended Conditions
Store tablets in a closed container at controlled room temperature (15–25°C), away from excessive heat, moisture, and direct light. Keep the product in its original packaging until use.
Do not use if the packaging is damaged or if tablets appear discolored or degraded. Keep out of reach of children.
Quick Reference
Do & Don't
- Do store at 15–25°C
- Do keep in original packaging
- Do protect from moisture and light
- Don't expose to excessive heat
- Don't use if tablets appear discolored
- Don't store in bathroom or humid areas
What is Haloplex 10 mg used for?
Haloplex 10 mg contains fluoxymesterone, a Schedule III anabolic steroid. Historically, it was FDA-approved for male hypogonadism and breast cancer palliation, but all products are now discontinued. In non-medical bodybuilding contexts, it is referenced for strength and hardness, though this use is not approved.
How often should Haloplex 10 mg be taken?
The historical FDA dose was 5–20 mg daily for hypogonadism and 10–40 mg daily for breast cancer. Non-medical protocols reference 10–40 mg daily in short cycles, but these are not approved and carry significant hepatotoxicity risk.
Does Haloplex 10 mg require PCT?
Yes, in non-medical contexts, post-cycle therapy is commonly recommended because fluoxymesterone suppresses endogenous testosterone production. Typical protocols reference tamoxifen or clomiphene for 4 weeks after the last dose.
What does fluoxymesterone do?
Fluoxymesterone binds androgen receptors, promoting protein synthesis and male secondary sex characteristics. It is a potent oral androgen with high anabolic activity. A 1977 study showed it profoundly suppresses plasma testosterone levels, likely through a direct effect on Leydig cells rather than via gonadotropin suppression.
How long does fluoxymesterone take to work?
The elimination half-life is approximately 9.2 hours. Testosterone suppression occurs within 24 hours of beginning treatment. In non-medical contexts, subjective effects on aggression and workout intensity are typically noted within the first week.
Is fluoxymesterone the best oral steroid for strength?
No single oral steroid is universally superior. Fluoxymesterone is noted for potent androgenic effects and strength gains, but it is also one of the most hepatotoxic oral steroids due to its 17α-alkylated structure. Safer alternatives exist for most non-medical users.
What is the difference between Haloplex and Stanoplex?
Stanoplex 50 (stanozolol) is another 17α-alkylated oral steroid, but with less androgenic activity and a different side effect profile. Fluoxymesterone is more androgenic and more potent for strength, but also more virilizing.
What is the difference between Haloplex and Oxandroplex?
Oxandroplex (oxandrolone) is a milder oral anabolic steroid with less hepatotoxicity and a more favorable safety profile. Fluoxymesterone is significantly more potent and androgenic, with greater risks.
Is 10 mg of fluoxymesterone a lot?
10 mg is a moderate dose relative to the historical FDA range of 5–40 mg daily. However, fluoxymesterone is significantly more potent than testosterone milligram-for-milligram, and even low doses can suppress testosterone and stress the liver.
What strength is Haloplex 10 mg?
Haloplex 10 mg by Axiolabs contains 10 mg of fluoxymesterone per tablet. It is supplied as 50 tablets per package. This is a research presentation.
Is Haloplex 10 mg lab tested?
No laboratory report is currently published for this specific Haloplex 10 mg product listing. Axiolabs products are generally subject to quality control, but no third-party laboratory report is available for this batch at this time.
What are the warning signs of fluoxymesterone liver injury?
Warning signs include yellowing of the skin or eyes (jaundice), dark urine, pale stools, right-upper-quadrant pain, nausea, and loss of appetite. These symptoms require immediate discontinuation and medical evaluation. Fluoxymesterone is a documented cause of cholestatic hepatitis and hepatic neoplasms.
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