Axiolabs
Axiolabs
Sildenaplex 100 mg
Product Information
Compound Details
Active Substance
Sildenafil Citrate
Phosphodiesterase Type 5 (PDE5) Inhibitor
100 mg/tablet
Strength
100 mg/tablet
Package
20 or 100 Tablets
2,000 mg or 10,000 mg Total Labeled Content
Form
Oral Tablets
Drug Class
PDE5 Inhibitor
Estimated Half-Life
Approximately 4 Hours
Manufacturer
Axiolabs
Amount :
20 tabs
100 tabs
Shipping :
International
U.S. Domestic
Out of stock
- Overview
- Profile
- Usage
- Safety
- Shipping
- Storage
- FAQ
- Reviews
Product Overview
Sildenaplex 100 mg by Axiolabs
Sildenaplex 100 mg is an oral sildenafil citrate product manufactured by Axiolabs and supplied as 100 mg tablets in 20-tablet or 100-tablet packages.
Sildenafil Citrate Oral Tablet
Sildenaplex 100 mg contains sildenafil citrate, a selective inhibitor of cyclic guanosine monophosphate (cGMP)-specific phosphodiesterase type 5 (PDE5). Sildenafil citrate is the active substance in the well-known prescription medication Viagra, which was initially approved by the U.S. Food and Drug Administration in 1998 for the treatment of erectile dysfunction. The 100 mg strength represents the maximum recommended single dose for erectile dysfunction treatment according to FDA-approved labeling.
In clinical medicine, sildenafil citrate is indicated for erectile dysfunction and pulmonary arterial hypertension (under the brand name Revatio). For erectile dysfunction, the recommended starting dose is typically 50 mg, with the option to increase to a maximum of 100 mg or decrease to 25 mg based on effectiveness and toleration. In bodybuilding and performance-enhancement contexts, sildenafil is commonly referenced for its vasodilatory effects, which may enhance training pumps and blood flow. It is also occasionally referenced for erectile function support during cycles involving androgenic compounds that can affect libido or erectile quality.
Sildenafil works by inhibiting PDE5, an enzyme that breaks down cGMP in smooth muscle cells. By blocking PDE5, sildenafil increases cGMP levels, leading to smooth muscle relaxation and increased blood flow. This mechanism is responsible for its therapeutic effects in erectile dysfunction and pulmonary hypertension. In non-medical bodybuilding contexts, this vasodilation is sometimes referenced for improved nutrient delivery and muscle pumps during training, though such use falls outside approved indications and has not been established as safe or effective for that purpose.
Key Benefits of Sildenaplex 100 mg
- Potent PDE5 inhibitor for vasodilation and blood flow support
- 100 mg per tablet for maximum recommended single dose
- Rapid onset with peak effects within 0.5–2 hours
- Commonly referenced for training pumps in bodybuilding contexts
- Available in 20 or 100 tablet package sizes
Product Profile
Sildenafil Citrate Profile
Sildenafil citrate is a selective PDE5 inhibitor with a well-characterized mechanism of action, rapid onset, and a relatively short duration of activity compared to other PDE5 inhibitors.
Selective PDE5 Inhibitor
Sildenafil citrate is designated chemically as 1-[[3-(6,7-dihydro-1-methyl-7-oxo-3-propyl-1H-pyrazolo[4,3-d]pyrimidin-5-yl)-4-ethoxyphenyl]sulfonyl]-4-methylpiperazine citrate. It acts as a highly selective inhibitor of cGMP-specific PDE5, which is responsible for degradation of cGMP in smooth muscle cells. By inhibiting PDE5, sildenafil increases cGMP levels, resulting in smooth muscle relaxation and vasodilation.
The oral bioavailability of sildenafil is approximately 41%, and it reaches peak plasma concentrations in 0.5–2 hours on an empty stomach. A high-fat meal can delay absorption and reduce peak concentration by approximately 29%. The plasma half-life is approximately 4 hours, and the duration of useful effect is generally 4–5 hours.
Sildenafil is selective for PDE5, with greater potency against PDE5 than other known phosphodiesterases including PDE6 (10-fold), PDE1 (80-fold), and PDE2, PDE3, PDE4, PDE7 and others (700-fold or greater). This selectivity underlies its therapeutic profile and adverse effect profile.
Defining Characteristic
Rapid Onset, Short Duration
Sildenafil's relatively short half-life of approximately 4 hours distinguishes it from longer-acting PDE5 inhibitors like tadalafil. This makes it suitable for time-specific use rather than chronic daily coverage.
Sildenaplex 100 mg vs Other Axiolabs Preparations
Axiolabs produces several products referenced in different contexts within bodybuilding. Sildenaplex 100 mg is a sildenafil citrate product, distinguishing it from longer-acting PDE5 inhibitors. For a longer-acting alternative in the same functional category, Taldenaplex offers tadalafil, which has a substantially longer half-life and is often referenced for daily use.
Sildenaplex is not an anabolic steroid and is not used for muscle growth or hormone manipulation. It is also distinct from ancillary products used for estrogen management such as Arimiplex or Exeplex, and from post-cycle therapy agents such as Clomiplex and Tamoxiplex.
Dosage & Usage
Sildenaplex 100 mg Dosage & Usage
The information below is provided for educational reference only. Sildenafil citrate is a prescription medication; medical use requires appropriate diagnosis and clinical supervision. Non-medical use falls outside approved indications.
Typical Dosage Ranges
In FDA-approved labeling, the recommended dose of sildenafil for erectile dysfunction is 50 mg taken approximately 1 hour before sexual activity, with a maximum recommended dose of 100 mg and a maximum dosing frequency of once per day. In non-medical bodybuilding contexts, sildenafil is commonly referenced at lower doses of 20–25 mg for daily use to support training pumps and blood flow, and at 50–100 mg for on-demand use.
| Use Case | Common Reference Range | Frequency |
|---|---|---|
| Medical ED (FDA-labeled) | 50 mg (max 100 mg) | Once daily, ~1 hour before activity |
| Bodybuilding (non-medical, daily pump) | 20–25 mg | Once daily or pre-training |
| Bodybuilding (non-medical, on-demand) | 50–100 mg | As needed, max once per day |
Stacking & Cycle Considerations
Sildenafil is not a cycle compound and does not interact with the hormonal mechanisms targeted by anabolic steroids. In bodybuilding contexts, it is sometimes referenced alongside cycles involving compounds that may affect erectile function or blood pressure, such as Trenaplex A 100 or Decaplex 250. It is not suppressive to the hypothalamic-pituitary-gonadal axis and does not require cycle planning or PCT.
Managing Side Effects
Common side effects reported in clinical studies include headache, flushing, dyspepsia, nasal congestion, and visual disturbances. These effects are typically transient and related to the vasodilatory mechanism. Higher doses are associated with increased frequency and severity of these effects.
Sildenafil should not be used with nitrates or nitric oxide donors in any form, as this combination can cause a life-threatening drop in blood pressure. This is an absolute contraindication.
Post-Cycle Therapy (PCT)
Sildenafil does not require post-cycle therapy and does not affect endogenous testosterone production. PCT is not applicable to sildenafil use.
Important
Individual Response Varies
Dosing strategies and support protocols should account for individual experience and health status. The information above is for educational reference and does not constitute medical advice.
Safety & Information
Sildenafil Citrate Safety Information
Sildenafil citrate is a prescription medication that can affect blood pressure and cardiovascular function. Medical use requires appropriate evaluation and clinical supervision.
Important Safety Information
Sildenafil has systemic vasodilatory properties that result in transient decreases in blood pressure, with a mean maximum decrease of 8.4/5.5 mmHg in healthy volunteers. While this is generally of little consequence in healthy individuals, it can be significant in patients with underlying cardiovascular disease or those taking antihypertensive medications.
The absolute contraindication for sildenafil is concomitant use of organic nitrates or nitric oxide donors in any form, including nitroglycerin, isosorbide mononitrate or dinitrate, and recreational substances known as "poppers" (amyl nitrate, butyl nitrate). This combination can produce life-threatening hypotension.
Important
Non-Medical Use
Sildenafil is not approved for bodybuilding or athletic performance enhancement. Non-medical use falls outside approved indications and may carry additional health risks beyond those associated with supervised medical use.
Potential Adverse Effects
The most common adverse effects reported in clinical trials include headache, flushing, dyspepsia, nasal congestion, and visual disturbances such as color tinge and increased light sensitivity. These effects are typically mild to moderate and transient.
Serious but rare adverse effects include sudden vision loss due to non-arteritic anterior ischemic optic neuropathy (NAION), sudden hearing loss, and priapism (prolonged erection lasting more than 4 hours). Priapism requires immediate medical attention to prevent permanent damage.
Cardiovascular events, including sudden cardiac death, myocardial infarction, and ventricular arrhythmias, have been reported in postmarketing experience, though a causal relationship has not been established. Men with preexisting cardiovascular disease should be evaluated before considering sildenafil use.
Conditions Requiring Medical Evaluation
Sildenafil should be used with caution in patients with anatomical deformation of the penis, conditions predisposing to priapism (sickle cell anemia, multiple myeloma, leukemia), bleeding disorders or active peptic ulceration, and retinitis pigmentosa. Medical evaluation is required before any consideration of use.
Monitoring During Therapy
Sildenafil is not typically associated with the routine laboratory monitoring required for anabolic steroids. Blood pressure should be monitored, particularly in individuals with hypertension or those taking antihypertensive medications. Visual changes should be evaluated promptly if they occur.
Product Care
Storage & Handling
Store tablets in a cool, dry place away from direct light and moisture. Keep in original packaging until use. Keep out of reach of children. Do not use if the product appears damaged or compromised.
Further Safety Information
Shipping & Authenticity
Shipping & Product Authenticity
Sildenaplex 100 mg is shipped in original manufacturer packaging with discreet, privacy-focused handling.
USA Domestic 3–5 business days
International 10–15 business days
Order Processing 24–48 business hours
Tracking Provided after dispatch
Direct Supply
Discreet Delivery & Original Packaging
Outer packaging remains discreet with no external product details. Products are supplied in original manufacturer presentation.
What to Expect
- Orders are processed after payment confirmation
- USA Domestic shipping is typically faster when local stock is selected
- International orders include tracking, though update frequency may vary
- Multiple warehouses may result in separate shipments when applicable
Authenticity Verification
To verify product authenticity, examine the packaging for manufacturer security features and compare against official Axiolabs presentation. Original packaging and consistent labeling help confirm product legitimacy.
For complete delivery details, please see our Shipping Info page.
Storage
Sildenaplex 100 mg Storage
Proper storage conditions help preserve product integrity and tablet stability.
Recommended Conditions
Store in a cool, dry place at controlled room temperature. Protect from excessive heat, moisture, and direct light. Keep tablets in their original packaging until use. Do not use if the product appears compromised or if tablets show signs of deterioration.
Keep out of reach of children. Follow proper handling practices.
Quick Reference
Do & Don't
- Do store in a cool, dry place
- Do keep in original packaging
- Do inspect before use
- Don't expose to excessive heat or moisture
- Don't store in direct sunlight
- Don't use if packaging is compromised
Frequently Asked Questions
Sildenaplex 100 mg FAQ
Answers to common questions about Sildenaplex 100 mg, sildenafil citrate, dosing, and product characteristics.
What is Sildenaplex 100 mg used for?
Sildenaplex 100 mg contains sildenafil citrate, a PDE5 inhibitor. In medical practice, it is approved for erectile dysfunction and pulmonary arterial hypertension. In non-medical bodybuilding contexts, it is commonly referenced for training pumps, blood flow support, and erectile function during cycles. Non-medical use falls outside approved indications.
How often should Sildenaplex 100 mg be taken?
For erectile dysfunction, FDA labeling specifies a maximum dosing frequency of once per day. In bodybuilding contexts, daily use at 20–25 mg or on-demand use at 50–100 mg is commonly referenced. Sildenafil has a relatively short half-life of approximately 4 hours, distinguishing it from longer-acting PDE5 inhibitors.
Does Sildenaplex 100 mg require PCT?
No. Sildenafil does not suppress the hypothalamic-pituitary-gonadal axis and does not affect endogenous testosterone production. Post-cycle therapy is not applicable to sildenafil use. It is not a hormonal compound and works through the nitric oxide/cGMP pathway rather than androgen receptor signaling.
What does sildenafil citrate do?
Sildenafil citrate inhibits PDE5, an enzyme that breaks down cGMP in smooth muscle cells. By blocking PDE5, it increases cGMP levels, leading to smooth muscle relaxation and increased blood flow. This mechanism underlies its therapeutic effects in erectile dysfunction and pulmonary hypertension. It also has mild vasodilatory effects that may contribute to its reputation for enhanced training pumps.
How long does sildenafil take to work?
Oral sildenafil reaches peak plasma concentrations in 0.5–2 hours on an empty stomach. A high-fat meal can delay absorption and reduce peak concentration by approximately 29%. The duration of useful effect is generally 4–5 hours, driven by the approximately 4-hour plasma half-life.
Is sildenafil the best PDE5 inhibitor for bodybuilding?
There is no universally "best" PDE5 inhibitor for bodybuilding. Sildenafil has a rapid onset and short duration, making it suitable for time-specific use. Taldenaplex (tadalafil) has a longer half-life and is often referenced for daily use. The appropriate choice depends on whether you want a time-locked window or chronic coverage.
What is the difference between sildenafil and tadalafil?
Sildenafil and tadalafil are both PDE5 inhibitors, but they differ in half-life and duration. Sildenafil has a half-life of approximately 4 hours and is typically referenced for on-demand use. Tadalafil has a substantially longer half-life, supporting daily or every-other-day use. Axiolabs offers Taldenaplex as its tadalafil product.
Is 100 mg of sildenafil a lot?
100 mg is the maximum recommended single dose for erectile dysfunction according to FDA labeling, with 50 mg being the recommended starting dose. In bodybuilding contexts, 100 mg is typically referenced for on-demand use rather than daily use. Sildenaplex 100 mg contains 100 mg per tablet, so each tablet represents the maximum recommended single dose.
What strength is Sildenaplex 100 mg?
Sildenaplex 100 mg is supplied as 100 mg sildenafil citrate tablets in 20-tablet or 100-tablet packages, giving 2,000 mg or 10,000 mg of total labeled sildenafil citrate content.
Can Sildenaplex 100 mg be taken with nitrates?
No. Concomitant use of sildenafil with organic nitrates or nitric oxide donors in any form is absolutely contraindicated. This combination can cause a life-threatening drop in blood pressure. Nitrates include medications for chest pain (nitroglycerin, isosorbide) and recreational substances known as "poppers" (amyl nitrate, butyl nitrate).
Does sildenafil affect blood pressure?
Yes. Sildenafil has systemic vasodilatory properties that result in transient decreases in blood pressure, with a mean maximum decrease of 8.4/5.5 mmHg in healthy volunteers. This effect is generally of little consequence in healthy individuals but can be significant in those with cardiovascular disease or those taking antihypertensive medications.
Is Sildenaplex 100 mg liver toxic?
Sildenafil is not hepatotoxic at therapeutic doses and does not carry the hepatic warnings associated with 17-alpha-alkylated anabolic steroids. Routine liver function monitoring is not typically required for sildenafil use. This distinguishes it from oral anabolic agents such as Methanoplex.
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Axiolabs
Product Information Compound Details
Active Substance Tadalafil Long-Acting Phosphodiesterase Type 5 (PDE5) Inhibitor
20 mgStrength 20 mg/tablet
Package 20 or 100 Tablets 400 mg or 2,000 mg Total Labeled Content
Form Oral Tablets
Drug Class PDE5 Inhibitor
Estimated Half-Life Approximately 17.5 Hours
Manufacturer Axiolabs