Ligandrol Oral
LGD 4033 15 mg contains ligandrol (LGD-4033), a nonsteroidal selective androgen receptor modulator (SARM). Ligandrol binds the androgen receptor with high affinity (Ki approximately 1 nM) and selectivity, and was investigated clinically for muscle wasting conditions and recovery from hip fracture. Unlike anabolic steroids, SARMs are designed to selectively activate androgen receptors in muscle and bone while minimizing activity in tissues such as the prostate.
Ligandrol has been studied in randomized, placebo-controlled trials in healthy men, demonstrating dose-dependent increases in lean body mass without significant changes in prostate-specific antigen in short-term use. It also dose-dependently suppressed total testosterone, sex hormone-binding globulin, HDL cholesterol, and triglyceride levels, with hormone levels returning to baseline after discontinuation. Ligandrol is not approved by the FDA for human use and is classified as an unapproved new drug when sold for human consumption.
In non-medical bodybuilding contexts, LGD 4033 is commonly referenced for lean muscle gains and strength increases, though such use falls outside approved indications. As a SARM, ligandrol is prohibited by the World Anti-Doping Agency (WADA) and is associated with risks including hormonal suppression and potential liver injury. Non-medical use for performance or physique enhancement is not recommended.
Key Benefits of LGD 4033 15 mg
- Selective androgen receptor modulator with high AR affinity
- Demonstrated dose-dependent increases in lean body mass in clinical trials
- Half-life of approximately 24–36 hours for once-daily dosing
- Not a steroid and not aromatizing
- 15 mg tablet strength for flexible dosing
Selective Androgen Receptor Modulator
Ligandrol is a nonsteroidal SARM that binds the androgen receptor with high affinity and selectivity. Its mechanism involves selective activation of androgenic signaling in muscle and bone, with less activity in prostate tissue compared to traditional androgens. Preclinical data suggests anabolic-to-androgenic ratios exceeding 500:1 in animal models.
The half-life of ligandrol is commonly referenced as approximately 24–36 hours, supporting once-daily dosing. A clinical trial reported that LGD-4033 had a long elimination half-life and dose-proportional accumulation upon multiple dosing.
In clinical trials, ligandrol increased lean body mass dose-dependently over 21 days at doses of 0.1, 0.3, and 1.0 mg daily. It also suppressed total testosterone, SHBG, HDL cholesterol, and triglycerides, with hormone levels returning to baseline after discontinuation.
Defining Characteristic
Nonsteroidal SARM with Long Half-Life
Ligandrol is a nonsteroidal SARM with a half-life of approximately 24–36 hours. Its selectivity for muscle and bone over prostate distinguishes it mechanistically from traditional anabolic steroids.
LGD 4033 15 mg vs Other Dragon Pharma Preparations
Dragon Pharma offers multiple compounds discussed in bodybuilding and performance contexts. Ligandrol's SARM mechanism contrasts with anabolic steroids such as Anavar 50 or Winstrol 50, which act as full androgen receptor agonists and carry 17-alpha-alkylation or injectable administration. It is also distinct from MK 2866 (ostarine), another SARM, and RAD 140, which has a different selectivity profile. Ligandrol is not a PPARδ agonist like GW501516 and does not share that compound's metabolic mechanism.
The distinction between LGD 4033 and these compounds is primarily one of receptor selectivity, half-life, and clinical data availability.
View Report
April 18, 2025
Batch #HDLGD23
Measured Result
15.66 mg
104.40% of label claim
View Report
September 22, 2023
Batch #HDLGD23
Measured Result
12.73 mg
84.87% of label claim
Laboratory results apply to the specific tested sample represented in each published report and should not be interpreted as a measurement of every tablet or production batch.
Typical Dosage Ranges
Clinical trials have evaluated LGD-4033 at doses of 0.1, 0.3, and 1.0 mg per day for 21 days in healthy men. In non-medical bodybuilding contexts, LGD 4033 15 mg is commonly referenced in the range of 5–15 mg per day, with some users referencing doses up to 20 mg per day. These doses are substantially higher than those used in clinical research and are not supported by safety data.
| Use Case |
Common Reference Range |
Frequency |
| Clinical trial (historical) |
0.1–1.0 mg / day |
Once daily |
| Beginner (non-medical) |
5–10 mg / day |
Once daily |
| Intermediate (non-medical) |
10–15 mg / day |
Once daily |
| Advanced (non-medical) |
15–20 mg / day |
Once daily |
Stacking & Cycle Considerations
In non-medical contexts, LGD 4033 is frequently referenced in standalone cycles or stacked with other SARMs such as MK 2866 or RAD 140. It may also be combined with a testosterone base to mitigate suppression, though stacking SARMs has not been evaluated in clinical trials and increases the risk of unknown interactions. Cycle duration is commonly referenced as 8–12 weeks in non-medical discussion.
Post-cycle therapy is commonly referenced after LGD 4033 cycles because ligandrol suppresses endogenous testosterone production, as demonstrated by dose-dependent suppression of total testosterone in clinical trials.
Managing Side Effects
Ligandrol suppresses testosterone, SHBG, HDL cholesterol, and triglycerides in a dose-dependent manner. Hormone levels returned to baseline after discontinuation in clinical trials, but the long-term effects of repeated or high-dose use are unknown. Cases of drug-induced liver injury have been reported with LGD-4033 use, particularly at doses far exceeding clinical trial levels.
Post-Cycle Therapy (PCT)
Because ligandrol suppresses endogenous testosterone production, post-cycle therapy is commonly recommended in non-medical contexts to help restore natural hormone function. Agents such as Clomid or Nolvadex are commonly referenced for this purpose. In clinical trials, hormone levels returned to baseline by day 56 after discontinuation without intervention, but this may not apply to higher non-medical doses.
Important
Individual Response Varies
Ligandrol is not approved for human use. The information above is for educational reference and does not constitute medical advice. Non-medical use is strongly cautioned against.
Important Safety Information
Ligandrol is an investigational SARM that has not been approved by the FDA for any human indication. Products marketed as LGD-4033 are considered unapproved new drugs when sold for human consumption. The FDA has issued warning letters to companies selling SARMs, citing safety concerns including life-threatening reactions, liver toxicity, and potential increased risk of heart attack and stroke.
Important
Non-Medical Use
Ligandrol has no approved human indication. Non-medical use falls outside approved indications and carries health risks including hepatotoxicity, hormonal suppression, and unknown long-term effects. Product strength and laboratory verification do not establish safety for human consumption.
Potential Adverse Effects
Hormonal suppression: Ligandrol dose-dependently suppresses total testosterone, free testosterone, SHBG, and FSH. In a 21-day clinical trial at doses up to 1.0 mg, suppression was observed and hormone levels returned to baseline by day 56 after discontinuation. At non-medical doses of 5–20 mg, suppression is likely more pronounced and recovery may take longer.
Liver injury: Cases of drug-induced liver injury have been reported with LGD-4033 use, including a documented case of cholestatic hepatitis with fibrosis.
Lipid changes: Ligandrol reduced HDL cholesterol and triglycerides in clinical trials.
Cardiovascular risk: The FDA has stated that SARMs, including LGD-4033, have the potential to increase the risk of heart attack and stroke.
Conditions Requiring Medical Evaluation
Given the potential for hormonal suppression and liver injury, any consideration of ligandrol exposure warrants comprehensive medical evaluation including liver function tests, lipid panel, and hormonal assessment. Individuals with pre-existing liver disease, cardiovascular disease, or hormonal disorders are at heightened risk. Athletes subject to drug testing should be aware that LGD-4033 is prohibited by WADA at all times.
Monitoring During Therapy
There is no established monitoring protocol for non-medical ligandrol use. For any human exposure, liver function tests, lipid panel, testosterone levels, and general health assessment should be assessed by a qualified healthcare professional. No safe monitoring parameters have been established for non-medical doses because human safety data at those doses is inadequate.
Product Care
Storage & Handling
Store in a cool, dry place away from direct light and moisture. Keep the product in its original packaging and out of the reach of children. This product is not for human consumption.
Further Safety Information
USA Domestic
3–5 business days
International
10–15 business days
Order Processing
24–48 business hours
Tracking
Provided after dispatch
Direct Supply
Discreet Delivery & Original Packaging
The outer shipping package remains discreet, with privacy-focused handling and no unnecessary external product details. Products are supplied through the Dragon Pharma distribution chain.
What to Expect
- Orders are processed after payment confirmation
- USA Domestic shipping is typically faster when local stock is selected
- International orders include tracking, though update frequency may vary by destination
- Multiple warehouses may result in separate shipments when applicable
Authenticity Verification
To verify your LGD 4033 15 mg product, cross-check the security features on the packaging against Dragon Pharma's official presentation. Batch-linked lab proof and original packaging help reinforce product legitimacy.
For complete delivery details, tracking policy, and reshipment terms, please see our Shipping Info page.
Recommended Conditions
Store in a cool, dry place away from excessive heat, moisture, and direct light. Maintaining stable conditions helps preserve the integrity of the tablets.
Keep the tablets in their original packaging until use. Do not use if the packaging appears compromised or if the tablets show signs of degradation such as discoloration or crumbling.
Keep out of reach of children. This product is not for human consumption.
Quick Reference
Do & Don't
- Do store in a cool, dry place
- Do keep in original packaging
- Do inspect tablets before use
- Don't expose to direct sunlight
- Don't store in humid environments
- Don't use if tablets appear abnormal
What is LGD 4033 15 mg used for?
LGD 4033 15 mg contains ligandrol, a SARM. It has no approved medical use. In non-medical bodybuilding contexts, it is commonly referenced for lean muscle gains and strength increases, though such use falls outside approved indications and carries health risks.
How often should LGD 4033 15 mg be taken?
Ligandrol has a half-life commonly referenced as approximately 24–36 hours, supporting once-daily dosing. In non-medical contexts, it is typically referenced as being taken once daily, with doses ranging from 5–20 mg per day.
Does LGD 4033 15 mg require PCT?
Yes. Ligandrol suppresses endogenous testosterone production, as demonstrated by dose-dependent suppression of total testosterone in clinical trials. In non-medical contexts, post-cycle therapy is commonly recommended. Agents such as Clomid or Nolvadex are commonly referenced for this purpose.
What does ligandrol do?
Ligandrol is a nonsteroidal SARM that binds the androgen receptor with high affinity and selectivity. It selectively activates androgenic signaling in muscle and bone, with less activity in prostate tissue compared to traditional androgens. Clinical trials demonstrated dose-dependent increases in lean body mass and suppression of testosterone, SHBG, and HDL cholesterol.
How long does LGD 4033 take to work?
In clinical trials, ligandrol increased lean body mass over a 21-day treatment period at doses of 0.1–1.0 mg per day. In non-medical contexts at higher doses, users often report noticeable changes in muscle mass and strength within the first 4–8 weeks of use.
Is LGD 4033 the best SARM?
There is no universally "best" SARM. Ligandrol is distinguished by its high androgen receptor affinity and clinical trial data showing lean mass increases. Other SARMs such as MK 2866 or RAD 140 have different selectivity profiles and side effect characteristics. The appropriate choice, if any, depends on individual goals and risk tolerance.
What is the difference between LGD 4033 and ostarine?
Both are SARMs, but they have different receptor selectivity profiles and half-lives. Ligandrol is considered more potent for muscle mass gains, while MK 2866 (ostarine) is often described as milder and is commonly referenced for joint support and cutting phases. Ligandrol has been studied in clinical trials at doses up to 1.0 mg, while ostarine has been studied at higher doses.
What is the difference between LGD 4033 and RAD 140?
Both are SARMs, but RAD 140 is generally considered more androgenic and is often referenced for strength and aggression, while ligandrol is referenced for lean mass gains. RAD 140 has not been studied in human clinical trials to the same extent as ligandrol.
Is 15 mg of LGD 4033 a lot?
Clinical trials used doses of 0.1–1.0 mg per day. In non-medical contexts, 15 mg per day is a commonly referenced dose, but it is substantially higher than clinical research doses and is not supported by safety data. LGD 4033 15 mg is labeled at 15 mg per tablet.
What strength is LGD 4033 15 mg?
LGD 4033 15 mg is labeled at 15 mg of ligandrol per tablet. It is supplied in a 100-tablet package, giving 1,500 mg of total labeled ligandrol content.
Is LGD 4033 15 mg lab tested?
Yes. Published laboratory reports for LGD 4033 15 mg are available. The most recent report dated April 18, 2025 measured the product at 15.66 mg per tablet, equivalent to 104.40% of its 15 mg label claim. Complete reports can be viewed in the Lab Reports tab.
Is ligandrol approved for human use?
No. Ligandrol is not approved by the FDA for human use and is classified as an unapproved new drug when sold for human consumption. It is prohibited by WADA at all times.
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