Testolone Oral
RAD 140 10 mg contains Testolone (also known as RAD140 or vosilasarm), a potent, orally bioavailable, nonsteroidal selective androgen receptor modulator (SARM). It binds the androgen receptor with high affinity (Ki of approximately 7 nM) and demonstrates selectivity over other steroid hormone nuclear receptors. Unlike anabolic steroids, RAD 140 is not a substrate for 5-alpha reductase and does not aromatize to estrogen.
In medical research, RAD 140 has been investigated as a potential treatment for AR+/ER+ metastatic breast cancer. A first-in-human Phase 1 study enrolled 22 heavily pretreated patients and established a maximum tolerated dose of 100 mg/day, with one partial response observed in a patient with an ESR1 mutation. The study reported frequent treatment-emergent adverse events including elevated AST (59.1%), ALT (45.5%), and total bilirubin (27.3%), with Grade 3/4 events occurring in 72.7% of patients. RAD 140 has **never received FDA approval for any indication**.
In bodybuilding and performance-enhancement contexts, RAD 140 is referenced for its anabolic effects on muscle mass, strength, and recovery. However, the FDA has not approved RAD 140 for human use, and multiple case reports document severe cholestatic liver injury, myopericarditis, and arterial thrombosis in young bodybuilders using unregulated products. The NCBI Bookshelf classifies SARMs including RAD 140 as a "likely cause of clinically apparent liver injury with jaundice". Such use falls outside any approved indication.
Research Properties of RAD 140 10 mg
- Nonsteroidal selective androgen receptor modulator (SARM)
- High AR binding affinity (Ki ~7 nM) with tissue selectivity
- Investigated in Phase 1 trials for AR+/ER+ metastatic breast cancer
- Orally bioavailable with good stability in human microsomes
- 10 mg per tablet for research applications
Nonsteroidal SARM
RAD 140 belongs to the selective androgen receptor modulator class, which aims to provide the anabolic benefits of androgens while minimizing androgenic side effects in tissues like prostate and skin. It binds AR with high affinity and activates AR in breast cancer cells but not prostate cancer cells, suggesting tissue-selective activity.
The compound has demonstrated neuroprotective effects in preclinical models, mitigating apoptotic insult-induced cell death in cultured hippocampal neurons through a mechanism dependent on MAPK/ERK signaling. In vivo, RAD 140 was neuroprotective in a rat kainate lesion model.
RAD 140's pharmacokinetic profile includes a half-life of approximately 44-60 hours in humans, supporting once-daily dosing. The compound is orally bioavailable with high stability in human microsomes.
Defining Characteristic
Androgen Receptor Selectivity
RAD 140's defining research characteristic is its tissue-selective AR activation, with high anabolic activity in muscle and bone but reduced androgenic effects in prostate and skin compared to steroidal androgens.
RAD 140 10 mg vs Other Dragon Pharma Preparations
Dragon Pharma offers several compounds referenced in bodybuilding research. MK 2866 (ostarine) is another SARM with a different selectivity profile and less potent anabolic activity. LGD 4033 (ligandrol) is a SARM investigated for muscle wasting. YK 11 is a steroidal SARM-like compound with a distinct mechanism. RAD 140's high AR affinity and specific tissue selectivity distinguish it from these compounds.
Typical Dosage Ranges
In the Phase 1 clinical trial for breast cancer, RAD 140 was administered at 50 mg, 100 mg, and 150 mg once daily, with 100 mg/day established as the maximum tolerated dose. In non-medical bodybuilding contexts, RAD 140 is commonly referenced at 10–20 mg per day, with cycles typically lasting 8 weeks. Reference ranges vary, and higher doses are associated with increased liver enzyme elevations and other adverse effects.
| Use Case |
Common Reference Range |
Frequency |
| Clinical trial (breast cancer) |
50–150 mg |
Once daily |
| Bodybuilding (non-medical) |
10–20 mg |
Once daily |
| Typical cycle length |
8 weeks (12 weeks max) |
Per cycle protocol |
Post-Cycle Therapy (PCT)
In non-medical bodybuilding contexts, post-cycle therapy is commonly recommended after RAD 140 cycles to restore endogenous testosterone production, as RAD 140 is suppressive to the hypothalamic-pituitary-gonadal axis. Typical PCT protocols reference tamoxifen 20 mg/day or enclomiphene 12.5–25 mg/day for 4 weeks, starting after the last dose. Recovery of testosterone production typically occurs within 4–8 weeks for most individuals, though recovery timelines vary.
Managing Side Effects
Liver enzyme elevations (ALT, AST) are commonly reported with RAD 140 use and should be monitored. N-acetyl cysteine (NAC) at 600–1200 mg/day or TUDCA at 250–500 mg/day may be used for hepatic support, particularly at doses above 15 mg/day or cycles exceeding 8 weeks. Testosterone suppression is dose-dependent and occurs in virtually all users by week 4–6.
Important
Individual Response Varies
The information above is for educational reference and does not constitute medical advice. RAD 140 has not been evaluated by the FDA for safety or efficacy in non-investigational applications.
Important Safety Information
The NCBI Bookshelf LiverTox database classifies SARMs including RAD 140 as a "likely cause of clinically apparent liver injury with jaundice" (Likelihood score: B). In published clinical trials, serum aminotransferase elevations occurred in 5% to 21% of patients, with isolated ALT elevations requiring drug discontinuation. In the Phase 1 breast cancer trial, Grade 3/4 treatment-emergent adverse events occurred in 72.7% of patients, including AST/ALT elevations and hypophosphatemia.
Important
FDA Warning on SARMs
The FDA has warned that SARMs including RAD 140 are not approved for human use and are illegally sold as dietary supplements. Documented adverse events include liver injury, heart failure, and myopericarditis.
Potential Adverse Effects
Documented adverse effects of RAD 140 in clinical and case-report settings include: cholestatic liver injury with jaundice (often requiring weeks of hospitalization); myopericarditis; arterial thrombosis with splenic and renal infarcts; testosterone suppression; HDL suppression and LDL elevation; hair shedding; headaches; nausea; and lipid disruption.
Hepatotoxicity cases in bodybuilders typically present with fatigue, anorexia, weight loss, abdominal pain, and pruritus followed by dark urine and jaundice, with latency of 2–3 months. Most cases resolve spontaneously after discontinuation, but some patients with severe jaundice develop renal dysfunction requiring temporary dialysis.
Conditions Requiring Medical Evaluation
RAD 140 should not be used by individuals with pre-existing liver disease, hepatitis, or baseline LFTs >1.5× ULN. Heavy alcohol use is incompatible. Stacking with oral 17α-alkylated steroids (superdrol, anadrol, dianabol, winstrol, anavar) significantly increases hepatic risk. Pregnancy, lactation, or plans to conceive within 6–12 months are contraindications due to poorly characterized fertility recovery. Pre-existing cardiovascular disease or uncontrolled hypertension is a contraindication.
Monitoring Considerations
If RAD 140 is used in any research context, monitoring of liver enzymes (AST/ALT), lipids, and hormones (total testosterone, free testosterone, estradiol, LH, FSH) is recommended. Liver enzyme elevations >3× ULN warrant discontinuation. Testosterone levels should be monitored to assess suppression and guide PCT decisions.
Product Care
Storage & Handling
Store tablets in a cool, dry place in the original packaging, protected from light and moisture. Keep out of reach of children.
Further Safety Information
USA Domestic 3–5 business days
International 10–15 business days
Order Processing 24–48 business hours
Tracking Provided after dispatch
Direct Supply
Discreet Delivery & Original Packaging
The outer shipping package remains discreet, with no external product details. Products are supplied through the official Dragon Pharma distribution chain.
What to Expect
- Orders are processed after payment confirmation
- USA Domestic shipping is typically faster when local stock is available
- International orders include tracking, though update frequency may vary by destination
- Multiple warehouses may result in separate shipments when applicable
Authenticity Verification
To verify your RAD 140 10 mg product, use the security code on the packaging and cross-check it on the official Dragon Pharma site. A credible certificate of analysis should show HPLC purity above 95 percent and mass spectrometry confirmation of the correct molecular weight (393.83 Da for Testolone). Original packaging and batch documentation help reinforce product legitimacy.
For complete delivery details, tracking policy, and reshipment terms, please see our Shipping Info page.
Recommended Conditions
Store tablets in a cool, dry place at controlled room temperature, protected from excessive heat, moisture, and direct light. Keep the product in its original packaging until use.
Do not use if the packaging is damaged or if tablets appear discolored or degraded. Keep out of reach of children.
Quick Reference
Do & Don't
- Do store in a cool, dry place
- Do keep in original packaging
- Do protect from moisture and light
- Don't expose to excessive heat
- Don't use if tablets appear discolored
- Don't store in bathroom or humid areas
What is RAD 140 10 mg used for?
RAD 140 10 mg is an oral tablet containing Testolone, a selective androgen receptor modulator (SARM). In medical research, it has been investigated for AR+/ER+ metastatic breast cancer. In non-medical bodybuilding contexts, it is referenced for muscle growth and strength, though such use falls outside approved indications.
How often should RAD 140 10 mg be taken?
In the Phase 1 clinical trial, RAD 140 was administered once daily at doses of 50–150 mg. In non-medical bodybuilding contexts, reference ranges typically cite 10–20 mg once daily. The compound's long half-life (approximately 44–60 hours) supports once-daily dosing.
Does RAD 140 10 mg require PCT?
Yes, in non-medical contexts, post-cycle therapy is commonly recommended because RAD 140 suppresses endogenous testosterone production. Typical PCT protocols reference tamoxifen or enclomiphene for 4 weeks starting after the last dose. Recovery of testosterone production typically occurs within 4–8 weeks.
What does Testolone do?
Testolone (RAD 140) binds the androgen receptor with high affinity and activates AR-mediated signaling in muscle and bone with reduced androgenic activity in prostate and skin compared to steroidal androgens. It has also demonstrated neuroprotective effects in preclinical models through MAPK/ERK-dependent mechanisms.
How long does RAD 140 take to work?
In non-medical reports, subtle improvements in energy and workout motivation may appear within 1–2 weeks, with noticeable strength gains by weeks 3–4 and peak anabolic effects at weeks 5–8. Testosterone suppression becomes measurable by week 4–6 in most users.
Is RAD 140 the best SARM?
No single SARM is universally superior. RAD 140 has high AR affinity and tissue selectivity that distinguishes it from MK 2866 (ostarine) and LGD 4033 (ligandrol). However, RAD 140 is associated with documented hepatotoxicity and cardiovascular risks, and is not FDA-approved.
What is the difference between RAD 140 and LGD 4033?
RAD 140 and LGD 4033 are both SARMs but have different selectivity profiles and potencies. RAD 140 has a higher AR binding affinity (Ki ~7 nM). Both carry hepatotoxicity risks and are unapproved for human use.
What is the difference between RAD 140 and MK 2866?
MK 2866 (ostarine) is a SARM with lower anabolic potency and a different selectivity profile than RAD 140. Both are unapproved for human use and associated with liver enzyme elevations.
Is 10 mg of RAD 140 a lot?
10 mg is the per-tablet strength of the Dragon Pharma RAD 140 product. In non-medical contexts, 10 mg daily is commonly referenced as a starting dose, with 20 mg being the upper end of typical use. The Phase 1 clinical trial used substantially higher doses (50–150 mg).
What strength is RAD 140 10 mg?
RAD 140 10 mg by Dragon Pharma contains 10 mg of Testolone per tablet. It is supplied as 100 oral tablets per package. This is a research presentation.
Can RAD 140 be stacked with other compounds?
In non-medical contexts, RAD 140 is sometimes referenced alongside MK 677 for complementary anabolic effects. However, stacking multiple SARMs compounds the risk of testosterone suppression, liver enzyme elevation, and lipid disruption without proportional benefit. Stacking with oral 17α-alkylated steroids is particularly dangerous and associated with hospitalizations.
What are the warning signs of RAD 140 liver injury?
Warning signs include yellowing of skin or eyes (jaundice), persistent right-upper-quadrant pain, severe itching without rash, dark tea-colored urine, and pale stools. These symptoms require immediate discontinuation and medical evaluation. Liver injury from SARMs typically presents 2–3 months after starting use.
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