Important Safety Information
Methandienone is hepatotoxic, and prolonged use or high doses can lead to cholestatic jaundice, peliosis hepatis, and hepatic adenomas . Cases of severe cholestasis requiring months for liver enzyme normalization have been reported after as little as five days of use .
Methandienone can also cause elevated blood pressure and adverse changes to cholesterol levels, including decreased HDL and increased LDL, which may increase cardiovascular risk .
Important
Non-Medical Use
Methandienone's medical use has been discontinued in most countries, including the United States, where it is a controlled substance . Use for bodybuilding or performance enhancement falls outside approved medical indications and is associated with significant health risks, including liver damage and cardiovascular effects.
Potential Adverse Effects
Commonly reported side effects of methandienone include acne, oily skin, increased facial and body hair growth, and scalp hair loss . Estrogenic effects such as gynecomastia and fluid retention can also occur due to aromatization to methylestradiol .
Methandienone suppresses endogenous testosterone production, which can lead to testicular atrophy, decreased libido, and reduced sperm production . In women, virilization effects such as voice deepening, hirsutism, and menstrual irregularities may occur and can be irreversible .
Conditions Requiring Medical Evaluation
Methandienone is contraindicated in men with prostate or breast carcinoma and in patients with severe hepatic impairment, hypercalcemia, or hypercalciuria . It should be used with caution in patients with cardiovascular disorders, renal or hepatic impairment, epilepsy, migraine, diabetes, or conditions aggravated by fluid retention .
Women who are pregnant or breastfeeding should not use methandienone, as it can cause virilization of a female fetus .
Monitoring During Therapy
Liver function tests are recommended during methandienone use due to its hepatotoxic potential . Blood pressure and lipid profiles should also be monitored, particularly in individuals with cardiovascular risk factors.
Laboratory testing of the product itself, such as a published potency report, is separate from clinical monitoring of the person using methandienone. No published laboratory report is available for this specific product.
Product Care
Storage & Handling
Store in the original packaging, protected from excessive heat, moisture and direct light. Keep all medications out of the reach of children. Follow the storage instructions provided with the product packaging.
Further Safety Information