Important Safety Information
Methandienone is not FDA-approved for human use in the United States and is classified as a Schedule III controlled substance. It was withdrawn from the U.S. prescription drug market and is currently a controlled substance. Methandienone is banned by the World Anti-Doping Agency under section S1.1 (Anabolic Androgenic Steroids) and is prohibited at all times in sport.
Anabolic steroids can cause serious cardiovascular and hepatic adverse effects. Peliosis hepatis, hepatocellular carcinoma, and lipid abnormalities have been reported. Prolonged use increases risk of atherosclerosis and myocardial infarction.
Important
Not for Human Use
This product is sold as a research chemical and is not approved for human use. Products sold online under the name Danabol through research compound vendors are not FDA-regulated, have no verified manufacturing standards, and carry unknown contamination, dosing, and safety risks.
Potential Adverse Effects
Hepatotoxicity is a primary concern with methandienone. As a 17-alpha-alkylated steroid, it can cause cholestasis, hepatic adenomas, and liver cancer with prolonged use. A published case report documented severe cholestasis with bilirubin rising to 77.9 mg/dl and acute renal failure in a bodybuilder. A separate case report described fatal liver failure attributed to methandienone.
Cardiovascular risks include elevated blood pressure, reduced HDL cholesterol, increased LDL cholesterol, and cardiac hypertrophy. A double-blind clinical trial in elderly patients found that coronary mortality was significantly higher among those receiving methandienone. Animal studies demonstrated cardiac hypertrophy and reduced response to inotropic loads.
Hormonal effects include suppression of natural testosterone production, gynecomastia due to aromatization, testicular atrophy, and reduced fertility. Psychological effects may include mood swings, aggression, and irritability. Other common side effects include severe acne, oily skin, and hair loss in those predisposed to male pattern baldness. For women, virilization symptoms such as deepening of the voice and increased body hair can occur and may be irreversible.
Conditions Requiring Medical Evaluation
Methandienone is contraindicated in pregnancy, breastfeeding, known or suspected prostate cancer, male breast cancer, severe hepatic impairment, nephrotic syndrome, and hypercalcemia. It should be avoided in children due to premature epiphyseal closure.
Individuals with pre-existing cardiac, renal, or hepatic disease should use caution. Liver function, lipid profile, and cardiac status should be monitored if use is considered.
Monitoring During Research Use
No monitoring parameters have been established for methandienone outside clinical trial settings. In case reports, liver function tests, bilirubin, and renal function were used to assess hepatic and renal injury. Laboratory testing of the product itself, such as the published potency report shown in the Lab Reports tab, is separate from any clinical monitoring. Product testing does not assess individual health status or suitability for use.
Product Care
Storage & Handling
Oral tablets should be stored at controlled room temperature (15–25°C) in the original packaging, protected from excessive heat, moisture, and direct light. Keep out of reach of children.
Methandienone is a Schedule III controlled substance and should be handled and disposed of according to local regulations.
Further Safety Information