Important Safety Information
FDA labeling for oxymetholone includes black box warnings for peliosis hepatis (blood-filled cysts in the liver that can lead to life-threatening liver failure or intra-abdominal hemorrhage), liver cell tumors (most often benign and androgen-dependent, but fatal malignant tumors have been reported), and blood lipid changes associated with increased risk of atherosclerosis and coronary artery disease.
Anabolic steroids may cause suppression of clotting factors II, V, VII and X, and an increase in prothrombin time. Clinically significant pharmacokinetic and pharmacodynamic interactions between anabolic steroids and warfarin have been reported in healthy volunteers.
Important
Not for Human Use
This product is sold as a research chemical and is not approved for human use. Products sold online under the name Oxymetholone through research compound vendors are not FDA-regulated, have no verified manufacturing standards, and carry unknown contamination, dosing, and safety risks. Oxymetholone is legally available only by prescription for approved medical indications.
Potential Adverse Effects
Hepatotoxicity is a primary concern. A two-year carcinogenicity study in rats given oxymetholone orally found increased incidences of lung alveolar/bronchiolar adenoma and hepatocellular adenoma in female rats at doses of 30 mg/kg/day and 100 mg/kg/day. There are rare reports of hepatocellular carcinoma in patients receiving long-term therapy with androgens in high doses.
Virilization in women may occur, including deepening of the voice, hirsutism, acne, and menstrual irregularities. Some virilizing changes are irreversible even after prompt discontinuance of therapy. Therapy must be discontinued when mild virilism is first detected.
Other potential effects include edema, increased blood pressure, acne, and changes in libido. Geriatric patients treated with androgens may be at increased risk of developing prostatic hypertrophy.
Conditions Requiring Medical Evaluation
Oxymetholone should be used very cautiously in children and only by specialists who are aware of the effects on bone maturation. Periodic x-ray examinations of bone age should be made during treatment of prepubertal patients.
Women with disseminated breast carcinoma should have frequent determination of urine and serum calcium levels during therapy. Patients with significant liver disease should not use this medication.
Monitoring During Therapy
Because of the hepatotoxicity associated with 17-alpha-alkylated androgens, liver function tests should be obtained periodically. Serum lipids and high-density lipoprotein cholesterol should be determined periodically. Hemoglobin and hematocrit should be checked periodically for polycythemia in patients receiving high doses.
Laboratory testing of the product itself, such as the published potency report shown in the Lab Reports tab, is separate from clinical monitoring of the person using the medication. Product testing does not assess individual health status or suitability for use.
Product Care
Storage & Handling
Oral tablets should be stored at controlled room temperature (15–25°C) in the original packaging, protected from excessive heat, moisture, and direct light. Keep out of reach of children.
Further Safety Information