Ipamorelin 5 mg is a lyophilized pentapeptide growth hormone secretagogue research product manufactured by Peptide Hubs and supplied as a 5 mg/vial powder in a 2 mL vial.
Ipamorelin 5 mg contains ipamorelin, a synthetic pentapeptide that acts as a selective growth hormone secretagogue. Ipamorelin was developed by Novo Nordisk and is considered one of the most selective ghrelin receptor (GHS-R1a) agonists, producing GH release with minimal effects on cortisol, prolactin, and appetite compared to older GHRPs .
Ipamorelin works by activating the ghrelin receptor on pituitary somatotrophs, stimulating endogenous GH release. Its selectivity profile distinguishes it from GHRP-2 and GHRP-6, which produce broader hormonal effects including cortisol and prolactin elevation . The peptide has a short half-life of approximately 2 hours, producing a discrete GH pulse after administration .
Ipamorelin is not FDA-approved for any human indication. In non-medical bodybuilding contexts, it is commonly referenced for its potential to stimulate GH release with minimal side effects, often in combination with GHRH analogs such as CJC-1295 . However, the FDA has documented serious adverse events including death associated with GHRP-related substances and has raised concerns about the lack of characterization data .
Ipamorelin 5 mg is supplied as a lyophilized (freeze-dried) powder in a 2 mL vial. Reconstitution with an appropriate solvent is required before use in research contexts.
Ipamorelin is a pentapeptide with the sequence Aib-His-D-2-Nal-D-Phe-Lys-NH2 and a molecular weight of approximately 711.85 Da .
Ipamorelin belongs to the class of growth hormone secretagogues (GHS), which stimulate endogenous GH release through activation of the ghrelin receptor (GHS-R1a) . Unlike GHRH analogs that act on the GHRH receptor, ipamorelin targets the ghrelin receptor pathway, making it mechanistically distinct from compounds like CJC-1295 .
The peptide was designed for selectivity—at GH-releasing doses, ipamorelin does not meaningfully increase ACTH, cortisol, or prolactin . This profile contrasts with GHRP-2 and GHRP-6, which produce more pronounced cortisol and appetite effects . Ipamorelin’s pharmacokinetic profile includes a terminal half-life of approximately 2 hours, with peak GH levels occurring around 30–60 minutes after administration .
In non-medical bodybuilding contexts, ipamorelin is commonly referenced for its potential to stimulate pulsatile GH release without the hormonal spillover associated with less selective secretagogues. However, the FDA has documented serious adverse events including death associated with GHRP-related substances .
Ipamorelin is distinguished by its high selectivity for the ghrelin receptor, producing minimal effects on cortisol, prolactin, and appetite compared to older GHRPs. This selectivity is the basis for its common description as the “cleanest” growth hormone secretagogue in research discussions .
Peptide Hubs offers several growth hormone secretagogues for research. Within this lineup, CJC-1295 No DAC is commonly discussed alongside ipamorelin for its GHRH receptor activity, with the two peptides often combined for potential synergistic GH release .
For research comparing different ghrelin receptor agonists, GHRP-2 and GHRP-6 offer less selective alternatives with more pronounced appetite effects. For pre-mixed combinations, CJC-1295/Ipamorelin provides a dual-pathway approach. For research requiring a reconstitution solution, Bacteriostatic Water is the standard diluent for preparing lyophilized peptides like Ipamorelin 5 mg.
Published laboratory reports for Ipamorelin 5 mg are shown below with the test date, measured content, and batch number.
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Laboratory results apply to the specific tested sample represented in each published report and should not be interpreted as a measurement of every vial or production batch.
The information below is provided for educational reference only. Ipamorelin is not an FDA-approved human drug. Its use for any non-medical purpose falls outside approved indications, and no established human dosing regimen exists .
Because ipamorelin lacks FDA approval and published human dose-finding trials for non-diagnostic applications, there is no medically established dosage range. In non-medical bodybuilding and research communities, reference ranges are derived from community convention. Commonly referenced ranges are 100–200 mcg per injection, administered 1–3 times daily .
| Use Case | Common Reference Range | Injection Frequency |
|---|---|---|
| Standard research protocol (non-medical) | 100–200 mcg | 1–3 times daily |
| Combined with CJC-1295 (non-medical) | 100–200 mcg IPA + CJC | 1–2 times daily |
| Upper range (non-medical) | 200 mcg | Once daily |
Community protocols commonly reference dosing in a fasted state, typically before bed and/or post-workout to align with natural GH pulses.
Ipamorelin 5 mg is supplied as a lyophilized powder and requires reconstitution before use. A 5 mg vial reconstituted with 2 mL of solvent yields a concentration of 2.5 mg/mL (2,500 mcg/mL), meaning a 100 mcg dose would require drawing 0.04 mL (4 units on a U-100 insulin syringe).
Reconstituted solution should be stored refrigerated at 2–8°C and protected from light. Avoid repeated freeze-thaw cycles.
In non-medical bodybuilding contexts, ipamorelin is frequently combined with GHRH analogs such as CJC-1295 No DAC for synergistic GH release, as the two peptides target different receptors—the ghrelin receptor and the GHRH receptor, respectively . Cycle lengths commonly referenced range from 8 to 12 weeks on, followed by a 4-week break.
For research requiring a pre-mixed combination, CJC-1295/Ipamorelin offers a convenient alternative, though the ratio and concentration differ from self-prepared blends.
No human dose-response data for therapeutic outcomes exists for ipamorelin. All dosage information is derived from community convention and should not be interpreted as medical guidance.
Ipamorelin is not FDA-approved for any human use. The FDA has documented serious adverse events including death associated with GHRP-related substances and has raised concerns about the lack of characterization data .
Ipamorelin has not received FDA approval. The FDA’s 2023 review of peptide safety data documented serious adverse events including death associated with GHRP-6 and related compounds, and noted immunogenicity risk from impurities and aggregation .
As a peptide administered parenterally, ipamorelin may pose immunogenicity risks. The FDA has raised concerns about the lack of characterization data for GHRP-related substances, including critical data on impurities, aggregates, and endotoxins .
Ipamorelin is marketed as a research peptide, but it is not FDA-approved for any human indication. Non-medical use falls outside approved indications and carries documented serious risks associated with related compounds .
Ipamorelin’s selectivity profile—with minimal cortisol and prolactin co-stimulation—is considered a safety advantage over earlier-generation GHRPs. Common side effects in available data include injection site reactions, transient headache, flushing, and mild water retention .
Community discussions of ipamorelin also mention potential fatigue, dizziness, and numbness/tingling in extremities, though these reports are anecdotal. The FDA has documented serious adverse events including death associated with GHRP-related substances .
Given the documented serious adverse events associated with related compounds and absence of long-term safety data, any consideration of ipamorelin use should involve consultation with a qualified healthcare professional. Individuals with a history of cancer or strong family history of malignancy should exercise particular caution due to theoretical mitogenic concerns with GH/IGF-1 signaling .
No established monitoring protocol exists for non-medical ipamorelin use. Clinicians evaluating patients using GH-related peptides should consider monitoring IGF-1 levels, blood glucose, and potential injection site reactions .
Store lyophilized powder at -20°C, sealed, dry, and protected from light. Once reconstituted, store refrigerated at 2–8°C and use within the recommended timeframe. Avoid repeated freeze-thaw cycles. Keep out of reach of children.
Ipamorelin 5 mg is supplied through the official Peptide Hubs distribution chain and shipped in original manufacturer packaging with discreet handling.
The outer shipping package remains discreet, with privacy-focused handling. Products are supplied through the official Peptide Hubs distribution chain.
To verify your Ipamorelin 5 mg product, use the security code on the vial label and cross-check it on the Peptide Hubs official site. Original packaging and manufacturer presentation help reinforce product legitimacy.
For complete delivery details, tracking policy, and reshipment terms, please see our Shipping Info page.
Proper storage conditions help preserve peptide stability and integrity throughout shelf life.
Store lyophilized powder at -20°C, sealed, dry, and protected from light. Under these conditions, the dry powder is stable for extended periods.
Once reconstituted, store refrigerated at 2–8°C and use within the recommended timeframe. Avoid repeated freeze-thaw cycles to maintain peptide integrity.
Keep out of reach of children. Follow proper handling practices.
Answers to common questions about Ipamorelin 5 mg, growth hormone secretagogues, and research peptide handling.
Ipamorelin 5 mg contains ipamorelin, a selective ghrelin receptor agonist studied for its ability to stimulate endogenous growth hormone release. In non-medical bodybuilding contexts, it is commonly referenced for GH release with minimal side effects, though such use falls outside approved indications .
No established human dosing schedule exists. Community protocols commonly reference 1–3 daily subcutaneous injections at 100–200 mcg per dose, based on convention rather than clinical outcome data .
Ipamorelin does not suppress endogenous testosterone production and does not require post-cycle therapy in the way anabolic steroids do. However, any non-medical peptide use should be approached with caution given the documented serious adverse events associated with related compounds .
Ipamorelin is a selective ghrelin receptor agonist that stimulates growth hormone release from the pituitary . Unlike older GHRPs, it produces minimal effects on cortisol, prolactin, and appetite .
Ipamorelin has a half-life of approximately 2 hours, with peak GH levels occurring 30–60 minutes after administration . Community reports suggest sleep quality improvements may appear over 1–3 weeks of consistent use .
There is no universally “best” GH secretagogue. Ipamorelin is often described as the most selective, with minimal cortisol and prolactin effects, but CJC-1295 No DAC targets a different pathway and may be preferred depending on the goal .
Ipamorelin acts through the ghrelin receptor (GHS-R1a), while CJC-1295 No DAC acts through the GHRH receptor. They target different pathways and are sometimes combined for synergistic GH release, but they are not interchangeable .
Both Ipamorelin and GHRP-2 act through the ghrelin receptor. Ipamorelin is more selective for GH release with minimal cortisol and appetite effects, while GHRP-2 produces more pronounced appetite stimulation .
200 mcg is at the upper end of the range commonly referenced in community protocols (100–200 mcg per injection). The GH response to ipamorelin is described as saturable, meaning higher doses do not necessarily produce proportionally greater effects .
Ipamorelin 5 mg is labeled at 5 mg of ipamorelin per vial. It is supplied as a lyophilized powder in a 2 mL vial.
Yes. The latest published laboratory report dated January 12, 2026 measured Ipamorelin 5 mg at 4.65 mg, equivalent to 93.0% of its 5 mg label claim. The batch number is GAIPA12.
Store the lyophilized powder at -20°C, sealed, dry, and protected from light. Once reconstituted, refrigerate at 2–8°C and use within the recommended timeframe. Avoid repeated freeze-thaw cycles.